English
norskBlar i forfatter "Strøm, Morten Bøhmer"
Viser treff 1-3 av 3
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Efficient and scalable synthesis of α,α-disubstituted β-amino amides
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-12)A practical and efficient methodology for the preparation of 2-aminoethyl α,α-disubstituted β-amino amides in three steps from methyl cyanoacetate has been developed. The key step in the synthesis was the chemoselective reduction of the nitrile group in presence of an amide and aryl halide functionalities. Reduction with RANEY® Nickel catalyst, either with molecular hydrogen (8–10 bar) or under ... -
The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In ... -
α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-25)Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms. Biofilm control is ...
